Article
A highly sensitive and specific model for predicting HIV-1 tropism in treatment-experienced patients combining interpretation of V3 loop sequences and clinical parameters.
Journal of acquired immune deficiency syndromes (1999) - 1 Jan 2011
Sánchez Victoria, Masiá Mar, Robledano Catalina, Padilla Sergio, Lumbreras Blanca, Poveda Eva, De Mendoza Carmen, Soriano Vicente, Gutiérrez Félix
Abstract excerpt
BACKGROUND: Phenotypic assays are considered the gold standard for HIV-1 tropism assessment. However, they are expensive and not widely available. Genotypic assays may provide an easier alternative, but their sensitivity remains low. We hypothesize that combining clinical data with V3 sequences may improve the diagnostic accuracy of genotypic tools. METHODS: We analyzed clinical and biological data from 159...
Topics
- Adult
- Aged
- Female
- Genotype
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Humans
- Male
- Middle Aged
- Models, Genetic