Article
Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
Annals of human genetics - 1 Jul 2013
Jeff Janina M, Ritchie Marylyn D, Denny Joshua C, Kho Abel N, Ramirez Andrea H, Crosslin David, Armstrong Loren, Basford Melissa A, Wolf Wendy A, Pacheco Jennifer A, Chisholm Rex L, Roden Dan M, Hayes M Geoffrey, Crawford Dana C
Abstract excerpt
Electrocardiographic (ECG) measurements vary by ancestry. Genome-wide association studies (GWAS) have identified loci that contribute to ECG measurements; however, most are performed in Europeans collected from population-based cohorts or surveys. The strongest associations reported are in NOS1AP with QT interval and SCN10A with PR and QRS durations. The extent to which these associations can be generalized to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.