Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple independent genetic factors at NOS1AP modulate the QT interval in a multi-ethnic population.

PloS one - 1 Jan 2009

Arking Dan E, Khera Amit, Xing Chao, Kao W H Linda, Post Wendy, Boerwinkle Eric, Chakravarti Aravinda

Abstract excerpt

Extremes of electrocardiographic QT interval are associated with increased risk for sudden cardiac death (SCD); thus, identification and characterization of genetic variants that modulate QT interval may elucidate the underlying etiology of SCD. Previous studies have revealed an association between a common genetic variant in NOS1AP and QT interval in populations of European ancestry, but this finding has not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Death, Sudden, Cardiac

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Electrocardiography

Share to Ethnicity

Share to Heart Diseases

Share to Heart Rate

Share to Hispanic or Latino

Share to Linear Models

Source

Open in PubMed Open full text

Identifiers

PMID: 19180230
DOI: 10.1371/journal.pone.0004333
PMCID: PMC2628730

Genes

NOS1AP
SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple independent genetic factors at NOS1AP modulate the QT interval in a multi-ethnic population.PMID 19180230Read ↗

Associations between NOS1AP single nucleotide polymorphisms (SNPs) and QT interval duration in four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA).Semantic proximity Read ↗

Genetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam Study.Semantic proximity Read ↗

Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study.Semantic proximity Read ↗

A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.Semantic proximity Read ↗

Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations.Semantic proximity Read ↗

Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration.Semantic proximity Read ↗

Effect of Sex and Underlying Disease on the Genetic Association of QT Interval and Sudden Cardiac Death.Semantic proximity Read ↗

Common variants at ten loci modulate the QT interval duration in the QTSCD Study.Semantic proximity Read ↗

Fine mapping of QT interval regions in global populations refines previously identified QT interval loci and identifies signals unique to African and Hispanic descent populations.Semantic proximity Read ↗

Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations.Semantic proximity Read ↗

Fine-mapping and initial characterization of QT interval loci in African Americans.Semantic proximity Read ↗

Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.