Article
Atf4 regulates obesity, glucose homeostasis, and energy expenditure.
Diabetes - 1 Nov 2009
Seo Jin, Fortuno Edgardo S, Suh Jae Myoung, Stenesen Drew, Tang Wei, Parks Elizabeth J, Adams Christopher M, Townes Tim, Graff Jonathan M
Abstract excerpt
OBJECTIVE: We evaluate a potential role of activating transcription factor 4 (Atf4) in invertebrate and mammalian metabolism. RESEARCH DESIGN AND METHODS: With two parallel approaches-a fat body-specific green fluorescent protein enhancer trap screen in D. melanogaster and expression profiling of developing murine fat tissues-we identified Atf4 as expressed in invertebrate and vertebrate metabolic tissues. We...
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