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Article

The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation.

FEBS letters - 25 Apr 2005

Matsuo Ryu, Kubota Hiroyuki, Obata Tohru, Kito Keiji, Ota Kazuhisa, Kitazono Takanari, Ibayashi Setsuro, Sasaki Takuma, Iida Mitsuo, Ito Takashi

Abstract excerpt

Amino acid-starved yeast activates the eIF2alpha kinase Gcn2p to suppress general translation and to selectively derepress the transcription factor Gcn4p, which induces various biosynthetic genes to elicit general amino acid control (GAAC). Well-fed yeast activates the target of rapamycin (TOR) to stimulate translation via the eIF4F complex. A crosstalk was demonstrated between the pathways for GAAC and TOR...

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Identifiers

PMID: 15848184
DOI: 10.1016/j.febslet.2005.03.043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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