Article
4E-BP functions as a metabolic brake used under stress conditions but not during normal growth.
Genes & development - 15 Aug 2005
Teleman Aurelio A, Chen Ya-Wen, Cohen Stephen M
Abstract excerpt
4E-BP is an important regulator of overall translation levels in cells. By binding eIF4E, 4E-BP impairs recruitment of the 40S ribosomal subunit to the cap structure present at the 5'-end of all eukaryotic cellular mRNAs. 4E-BP activity is controlled by TOR (Target of Rapamycin). 4E-BP has been studied extensively in cell culture; however, the biological role of 4E-BP in developing organisms is unclear to date....
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