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Article

Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR.

Nature communications - 16 Sept 2020

Vasudevan Deepika, Neuman Sarah D, Yang Amy, Lough Lea, Brown Brian, Bashirullah Arash, Cardozo Timothy, Ryoo Hyung Don

Abstract excerpt

The Integrated Stress Response (ISR) helps metazoan cells adapt to cellular stress by limiting the availability of initiator methionyl-tRNA for translation. Such limiting conditions paradoxically stimulate the translation of ATF4 mRNA through a regulatory 5' leader sequence with multiple upstream Open Reading Frames (uORFs), thereby activating stress-responsive gene expression. Here, we report the identification...

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Identifiers

PMID: 32938929
DOI: 10.1038/s41467-020-18453-1
PMCID: PMC7495428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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