Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adenovirus-Mediated Overexpression of Septin 2 Attenuates α-Smooth Muscle Actin Expression and Adventitial Myofibroblast Migration Induced by Angiotensin II.

Journal of vascular research - 1 Jan 2016

Guo Shu-Jie, Zhang Peng, Wu Ling-Yun, Zhang Guan-Nan, Chen Wen-Dong, Gao Ping-Jin

Abstract excerpt

Phenotypic transformation from adventitial fibroblasts (AFs) to myofibroblasts (MFs) is critical for vascular remodeling. Septin 2 was found to be downregulated during the differentiation of AFs to MFs induced by angiotensin II (Ang II); however, the role of septin 2 in this process is still unknown. In this study, we investigate whether septin 2 contributes to the adventitial MF phenotypic modulation caused by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Adenoviridae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Angiotensin II

Share to Aorta, Thoracic

Share to Myofibroblasts

Share to rhoA GTP-Binding Protein

Share to Septins

Share to Tubulin

Source

Identifiers

PMID: 27974709
DOI: 10.1159/000452413

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adenovirus-Mediated Overexpression of Septin 2 Attenuates α-Smooth Muscle Actin Expression and Adventitial Myofibroblast Migration Induced by Angiotensin II.PMID 27974709Read ↗

Cellular repressor E1A-stimulated genes controls phenotypic switching of adventitial fibroblasts by blocking p38MAPK activation.Semantic proximity Read ↗

TGF-β1/FGF-2 signaling mediates the 15-HETE-induced differentiation of adventitial fibroblasts into myofibroblasts.Semantic proximity Read ↗

Loss of Acta2 in cardiac fibroblasts does not prevent the myofibroblast differentiation or affect the cardiac repair after myocardial infarctionSemantic proximity Read ↗

MMP-2 expression by fibroblasts is suppressed by the myofibroblast phenotype.Semantic proximity Read ↗

Smooth muscle alpha-actin expression and myofibroblast differentiation by TGFbeta are dependent upon MK2.Semantic proximity Read ↗

Angiotensin II Promotes the Phenotypic Transition of c-Kit+ Cardiac Interstitial Cells to Myofibroblasts Through Collagen Receptor Discoidin Domain Receptor 2.Semantic proximity Read ↗

Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial Monolayers.Semantic proximity Read ↗

Reversal of myofibroblast differentiation by prostaglandin E(2).Semantic proximity Read ↗

Effects of extracellular matrix on phenotype modulation and MAPK transduction of rat aortic smooth muscle cells in vitro.Semantic proximity Read ↗

Cytoskeletal remodeling in vascular smooth muscle cells in response to angiotensin II-induced activation of the SHP-2 tyrosine phosphatase.Semantic proximity Read ↗

Lack of MK2 inhibits myofibroblast formation and exacerbates pulmonary fibrosis.Semantic proximity Read ↗

Coordinate expression of alpha-tropomyosin and caldesmon isoforms in association with phenotypic modulation of smooth muscle cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.