Article
Coordinate expression of alpha-tropomyosin and caldesmon isoforms in association with phenotypic modulation of smooth muscle cells.
The Journal of biological chemistry - 13 Jun 1997
Kashiwada K, Nishida W, Hayashi K, Ozawa K, Yamanaka Y, Saga H, Yamashita T, Tohyama M, Shimada S, Sato K, Sobue K
Abstract excerpt
Isoform diversity of tropomyosin is generated from the limited genes by a combination of differential transcription and alternative splicing. In the case of the alpha-tropomyosin (alpha-TM) gene, exon 2a rather than exon 2b is specifically spliced in alpha-TM-SM mRNA, which is one of the major tr...
Topics
- Animals
- Calmodulin-Binding Proteins
- Cells, Cultured
- Chick Embryo
- Molecular Sequence Data
- Muscle, Smooth
- Phenotype
- RNA Splicing
- RNA, Messenger
- Transcription, Genetic
- Tropomyosin