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Cellular repressor E1A-stimulated genes controls phenotypic switching of adventitial fibroblasts by blocking p38MAPK activation.

Atherosclerosis - 1 Dec 2012

Li Yang, Tao Jie, Zhang Jian, Tian Xiaoxiang, Liu Shaowei, Sun Mingyu, Zhang Xiaolin, Yan Chenghui, Han Yaling

Abstract excerpt

AIMS: Phenotypic modulation of adventitial fibroblasts (AFs) plays an important role in the pathogenesis of proliferative vascular diseases. The current study aimed to identify the role of cellular repressor E1A-stimulated genes (CREG), a critical mediator in the maintenance of vascular homeostasis, in AF phenotypic modulation and adventitial remodeling. METHOD AND RESULTS: Using in situ double-immunofluorescence...

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PMID: 23040447
DOI: 10.1016/j.atherosclerosis.2012.08.015

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