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Article

Smooth muscle alpha-actin expression and myofibroblast differentiation by TGFbeta are dependent upon MK2.

Journal of cellular biochemistry - 15 Apr 2007

Sousa Anne Marie, Liu Tiegang, Guevara Oscar, Stevens Joanne, Fanburg Barry L, Gaestel Matthias, Toksoz Deniz, Kayyali Usamah S

Abstract excerpt

Fibroblasts play a major role in processes such as wound repair, scarring, and fibrosis. Differentiation into myofibroblasts, characterized by upregulation of smooth muscle alpha-actin (smalpha) in response to profibrotic agents such as TGFbeta is believed to be an important step in fibrosis. Therefore, elucidating mechanisms of myofibroblast differentiation might reveal novel targets in treating diseases such as...

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Identifiers

PMID: 17163490
DOI: 10.1002/jcb.21154
PMCID: PMC2586991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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