Article
Effects of extracellular matrix on phenotype modulation and MAPK transduction of rat aortic smooth muscle cells in vitro.
Experimental and molecular pathology - 1 Oct 2000
Qin H, Ishiwata T, Wang R, Kudo M, Yokoyama M, Naito Z, Asano G
Abstract excerpt
The transition of arterial smooth muscle cells (SMCs) from a contractile to a synthetic phenotype may play an essential role in the formation of atherosclerotic and restenotic lesions. This process includes a prominent structural reorganization and allows cells to acquire the ability to migrate, proliferate, and secrete extracellular matrix components. According to Western blotting analysis and...
Topics
- Actins
- Animals
- Cells, Cultured
- Enzyme Inhibitors
- Extracellular Matrix
- Fibronectins
- Flavonoids
- Laminin
- Microscopy, Electron
- Microscopy, Fluorescence
- Mitogen-Activated Protein Kinases
- Muscle, Smooth, Vascular
- Myosin Heavy Chains
- Phenotype