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Angiotensin II Promotes the Phenotypic Transition of c-Kit+ Cardiac Interstitial Cells to Myofibroblasts Through Collagen Receptor Discoidin Domain Receptor 2.

BioFactors (Oxford, England) - 1 Jan 2026

Devidasan Indraja, Radhakrishnan Sruthi, Gopal Sarayu, Nair Geethu S, Mundackal Sivaraman Divya, Pillai Vivek V, Mohan Neethu

Abstract excerpt

Angiotensin II (Ang II), a potent profibrotic stimulus, exhibits pleiotropic effects on cardiac cells. The fate of c-Kit+ cells in an Ang II-elevated injured myocardium remains poorly defined. This study investigated, in vitro, the effect of Ang II on the phenotype of non-hematopoietic non-endothelial c-Kit+ cardiac interstitial cells (CICs), expressing OCT4. Our findings demonstrate that Ang II directly drives...

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Identifiers

PMID: 42104562
DOI: 10.1002/biof.70108

Genes

DDR2
SRF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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