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Article

Loss of Acta2 in cardiac fibroblasts does not prevent the myofibroblast differentiation or affect the cardiac repair after myocardial infarction

22 Aug 2022

Abstract excerpt

In response to myocardial infarction (MI), quiescent cardiac fibroblasts differentiate into myofibroblasts mediating tissue repair. One of the most widely accepted markers of myofibroblast differentiation is the expression of Acta2 which encodes smooth muscle alpha-actin (SMαA) that is assembled into stress fibers. However, the requirement of Acta2/SMαA in the myofibroblast differentiation of cardiac fibroblasts...

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Share to Cardiac Fibrosis and Remodeling
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PMID: 36007455
DOI: 10.1016/j.yjmcc.2022.08.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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