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Article

Lack of MK2 inhibits myofibroblast formation and exacerbates pulmonary fibrosis.

American journal of respiratory cell and molecular biology - 1 Nov 2007

Liu Tiegang, Warburton Rod R, Guevara Oscar E, Hill Nicholas S, Fanburg Barry L, Gaestel Matthias, Kayyali Usamah S

Abstract excerpt

Fibroblasts play a major role in tissue repair and remodeling. Their differentiation into myofibroblasts, marked by increased expression of smooth muscle-specific alpha-actin (alpha-SMA), is believed to be important in wound healing and fibrosis. We have recently described a role for MK2 in this phenotypic differentiation in culture. In this article, we demonstrate that MK2 also regulates myofibroblasts in vivo....

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Source

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Identifiers

PMID: 17600313
DOI: 10.1165/rcmb.2007-0077OC
PMCID: PMC2048679

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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