Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TGF-β1/FGF-2 signaling mediates the 15-HETE-induced differentiation of adventitial fibroblasts into myofibroblasts.

Lipids in health and disease - 5 Jan 2016

Zhang Li, Chen Yan, Li Guixia, Chen Minggang, Huang Wei, Liu Yanrui, Li Yumei

Abstract excerpt

BACKGROUND: Pulmonary adventitial fibroblasts (PAFs) are activated under stress stimuli leading to their differentiation into myofibroblasts, which is involved in vessel remodeling. 15-HETE is known as an important factor in vessel remodeling under hypoxia; however, the role of 15-HETE in PAF phenotypic alteration is not clear. RESULTS: The effect of 15-HETE on PAF phenotypic alterations was investigated in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor 2

Share to Fibroblasts

Share to Myofibroblasts

Share to p38 Mitogen-Activated Protein Kinases

Share to Transforming Growth Factor beta1

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 26729053
DOI: 10.1186/s12944-015-0174-3
PMCID: PMC4700586

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TGF-β1/FGF-2 signaling mediates the 15-HETE-induced differentiation of adventitial fibroblasts into myofibroblasts.PMID 26729053Read ↗

15-Lipoxygenase/15-hydroxyeicosanoid and activator protein 1 contribute to hypoxia-induced pulmonary artery smooth muscle cells phenotype alteration.Semantic proximity Read ↗

The role and mechanism of NRF2 in endothelial cells and smooth muscle cells of pulmonary arterySemantic proximity Read ↗

Low-dose fluvastatin reverses the hypoxic pulmonary adventitial fibroblast phenotype in experimental pulmonary hypertension.Semantic proximity Read ↗

TGF-β-Induced Endothelial-Mesenchymal Transition in Fibrotic DiseasesSemantic proximity Read ↗

Hypoxia Inducible Factor-1α in Pulmonary Fibrosis: A Promising Therapeutic TargetSemantic proximity Read ↗

Reversal of myofibroblast differentiation by prostaglandin E(2).Semantic proximity Read ↗

Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms.Semantic proximity Read ↗

CREG mediated adventitial fibroblast phenotype modulation: a possible therapeutic target for proliferative vascular disease.Semantic proximity Read ↗

Research progress on the mechanism of phenotypic transformation of pulmonary artery smooth muscle cells induced by hypoxiaSemantic proximity Read ↗

Cellular repressor E1A-stimulated genes controls phenotypic switching of adventitial fibroblasts by blocking p38MAPK activation.Semantic proximity Read ↗

Role of endothelial cells in pulmonary fibrosis via SREBP2 activationSemantic proximity Read ↗

Prostaglandin E₂ Reverses Myofibroblast Differentiation in Eosinophilic EsophagitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.