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Article

Reversal of myofibroblast differentiation by prostaglandin E(2).

American journal of respiratory cell and molecular biology - 1 May 2013

Garrison Garth, Huang Steven K, Okunishi Katsuhide, Scott Jacob P, Kumar Penke Loka Raghu, Scruggs Anne M, Peters-Golden Marc

Abstract excerpt

Differentiation of fibroblasts into α-smooth muscle actin (SMA)-expressing myofibroblasts represents a critical step in the pathogenesis of fibrotic disorders, and is generally regarded as irreversible. Prostaglandin E2 (PGE2) has been shown to prevent multiple aspects of fibroblast activation, including the differentiation of fibroblasts to myofibroblasts. Here, we investigated its ability to reverse this...

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Identifiers

PMID: 23470625
DOI: 10.1165/rcmb.2012-0262OC
PMCID: PMC3707380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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