Article

Domains of methylated CAC and CG target MeCP2 to tune transcription in the brain

2016-11-14

Abstract excerpt

<h4>Summary</h4> Mutations in the gene encoding the methyl-CG binding protein MeCP2 cause neurological disorders including Rett syndrome. The di-nucleotide methyl-CG (mCG) is the canonical MeCP2 DNA recognition sequence, but additional targets including non-methylated sequences have been reported. Here we use brain-specific depletion of DNA methyltransferase to show that DNA methylation is the primary determinant...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 719052fa-5a50-55a4-bac1-d2fdbe8fdb20
DOI: 10.1101/087577

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Domains of methylated CAC and CG target MeCP2 to tune transcription in the brainDOI 10.1101/087577Read

Neuronal non-CG methylation is an essential target for MeCP2 functionSemantic proximity Read

Neuronal non-CG methylation is an essential target for MeCP2 function.Semantic proximity Read

DNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopmental disordersSemantic proximity Read

DNA methylation in the gene body influences MeCP2-mediated gene repression.Semantic proximity Read

MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological functionSemantic proximity Read

DNA methylation, nucleic acid structure, and rett mutations tune MeCP2 binding affinity and cooperativity.Semantic proximity Read

Loss of Dnmt3a dependent methylation in inhibitory neurons impairs neural function through a mechanism that impacts Rett syndromeSemantic proximity Read

DNA methylation and Rett syndrome.Semantic proximity Read

MECP2 MBD-ID Module: A Unified DNA/RNA Binding Interface Disrupted in Rett SyndromeSemantic proximity Read

Methyl-CpG binding proteins in the nervous system.Semantic proximity Read

Extending MeCP2 interactome: canonical nucleosomal histones interact with MeCP2.Semantic proximity Read

MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome.Semantic proximity Read