Article

Neuronal non-CG methylation is an essential target for MeCP2 function

2020-07-02

Abstract excerpt

<h4>SUMMARY</h4> DNA methylation is implicated in neuronal biology via the protein MeCP2, mutation of which causes Rett syndrome. MeCP2 recruits the NCOR1/2 corepressor complexes to methylated cytosine in the CG dinucleotide, but also to non-CG methylation, which is abundant specifically in neuronal genomes. To test the biological significance of its dual binding specificity, we replaced the MeCP2 DNA binding dom...

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Literature Corpus work: 458608fd-4639-5f87-bc0d-8612073ae03b
DOI: 10.1101/2020.07.02.184614

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