Article
Neuronal non-CG methylation is an essential target for MeCP2 function.
Molecular cell - 18 Mar 2021
Tillotson Rebekah, Cholewa-Waclaw Justyna, Chhatbar Kashyap, Connelly John C, Kirschner Sophie A, Webb Shaun, Koerner Martha V, Selfridge Jim, Kelly David A, De Sousa Dina, Brown Kyla, Lyst Matthew J, Kriaucionis Skirmantas, Bird Adrian
Abstract excerpt
DNA methylation is implicated in neuronal biology via the protein MeCP2, the mutation of which causes Rett syndrome. MeCP2 recruits the NCOR1/2 co-repressor complexes to methylated cytosine in the CG dinucleotide, but also to sites of non-CG methylation, which are abundant in neurons. To test the biological significance of the dual-binding specificity of MeCP2, we replaced its DNA binding domain with an...
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