Article
MeCP2 in neurons: closing in on the causes of Rett syndrome.
Human molecular genetics - 15 Apr 2005
Caballero Isabel Martín, Hendrich Brian
Abstract excerpt
The discovery in 1999 that Rett syndrome (RTT) is caused by mutations in a gene encoding the methyl-CpG-binding repressor protein MECP2 provided a significant breakthrough in the understanding of this devastating disease. The subsequent production of Mecp2 knockout mice 2 years later provided an experimental resource to better understand how mutations in the MECP2 gene result in RTT. This paper reviews the recent...
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