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Article

Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM.

Molecular cell - 5 Jan 2017

Zhou Yi, Lee Ji-Hoon, Jiang Wenxia, Crowe Jennie L, Zha Shan, Paull Tanya T

Abstract excerpt

Ataxia-telangiectasia mutated (ATM) regulates the DNA damage response as well as DNA double-strand break repair through homologous recombination. Here we show that ATM is hyperactive when the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is chemically inhibited or when the DNA-PKcs gene is deleted in human cells. Pre-incubation of ATM protein with active DNA-PKcs also significantly reduces ATM...

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Source

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Identifiers

PMID: 27939942
DOI: 10.1016/j.molcel.2016.11.004
PMCID: PMC5724035

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM.PMID 27939942Read ↗

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