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Article

Clinical potential of ATM inhibitors.

Mutation research - 1 Jan 2000

Lavin Martin F, Yeo Abrey J

Abstract excerpt

The protein defective in the human genetic disorder ataxia-telangiectasia, ATM, plays a central role in responding to DNA double strand breaks and other lesions to protect the genome against DNA damage and in this way minimize the risk of mutations that can lead to abnormal cellular behaviour. Its function in normal cells is to protect the cell against genotoxic stress but inadvertently it can assist cancer cells...

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Identifiers

PMID: 32304909
DOI: 10.1016/j.mrfmmm.2020.111695

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