Transient ATM Kinase Inhibition Disrupts DNA Damage–Induced Sister Chromatid Exchange

Abstract excerpt

Cells derived from ataxia telangiectasia (A-T) patients exhibit defective cell cycle checkpoints because of mutations in the gene encoding ATM (ataxia telangiectasia mutated). After exposure to ionizing radiation (IR), A-T cells exhibit sensitivity to IR-induced cellular damage that results in increased chromosome aberrations and cell death (radiosensitivity). ATM is a member of a family of kinases that become...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer-related Molecular Pathways
• Share to Carcinogens and Genotoxicity Assessment
• Share to DNA Repair Mechanisms