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Article

Ataxia telangiectasia mutated (ATM) kinase as a predictive biomarker in clinical oncology: implications for a precision treatment approach.

Neoplasia (New York, N.Y.) - 1 Jul 2026

Pham Ann T, Yuan Fenghua, Nagathihalli Nagaraj S, Dosch Austin R

Abstract excerpt

ATM (ataxia telangiectasia mutated) kinase is a central mediator of the DNA damage response (DDR), with established roles in maintaining genomic integrity in response to genotoxic insults. Both germline and somatic alterations in ATM occur frequently in tumors, with pathogenic variants affecting an estimated 1 in 100 individuals worldwide. Emerging evidence has shown its utility as a biomarker for therapeutic...

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Source

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Identifiers

PMID: 42025253
DOI: 10.1016/j.neo.2026.101309
PMCID: PMC13126285

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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