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Article

Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity.

Cancer research - 1 Mar 2017

Udyavar Akshata R, Wooten David J, Hoeksema Megan, Bansal Mukesh, Califano Andrea, Estrada Lourdes, Schnell Santiago, Irish Jonathan M, Massion Pierre P, Quaranta Vito

Abstract excerpt

Small cell lung cancer (SCLC) is a devastating disease due to its propensity for early invasion and refractory relapse after initial treatment response. Although these aggressive traits have been associated with phenotypic heterogeneity, our understanding of this association remains incomplete. To fill this knowledge gap, we inferred a set of 33 transcription factors (TF) associated with gene signatures of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27932399
DOI: 10.1158/0008-5472.CAN-16-1467
PMCID: PMC5532541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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