Article

Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers

2018-12-26

Abstract excerpt

Adopting a systems approach, we devise a general workflow to define actionable subtypes in human cancers. Applied to small cell lung cancer (SCLC), the workflow identifies four subtypes based on global gene expression patterns and ontologies. Three correspond to known subtypes, while the fourth is a previously undescribed neuroendocrine variant (NEv2). Tumor deconvolution with subtype gene signatures shows that al...

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Literature Corpus work: bef78eda-a36b-57a0-bfdf-a807eaf38c0a
DOI: 10.1101/506402

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