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Article

Topological signatures in regulatory network enable phenotypic heterogeneity in small cell lung cancer.

eLife - 17 Mar 2021

Chauhan Lakshya, Ram Uday, Hari Kishore, Jolly Mohit Kumar

Abstract excerpt

Phenotypic (non-genetic) heterogeneity has significant implications for the development and evolution of organs, organisms, and populations. Recent observations in multiple cancers have unraveled the role of phenotypic heterogeneity in driving metastasis and therapy recalcitrance. However, the origins of such phenotypic heterogeneity are poorly understood in most cancers. Here, we investigate a regulatory network...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33729159
DOI: 10.7554/eLife.64522
PMCID: PMC8012062

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