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Article

Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers

31 Oct 2019

Abstract excerpt

Adopting a systems approach, we devise a general workflow to define actionable subtypes in human cancers. Applied to small cell lung cancer (SCLC), the workflow identifies four subtypes based on global gene expression patterns and ontologies. Three correspond to known subtypes (SCLC-A, SCLC-N, and SCLC-Y), while the fourth is a previously undescribed ASCL1+ neuroendocrine variant (NEv2, or SCLC-A2). Tumor...

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PMID: 31671086
DOI: 10.1371/journal.pcbi.1007343

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