Evaluation of in vivo gene mutation with etoposide using Pig-a and PIGRET assays.

doi:10.1016/j.mrgentox.2016.06.006

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Article

Evaluation of in vivo gene mutation with etoposide using Pig-a and PIGRET assays.

Mutation research. Genetic toxicology and environmental mutagenesis - 15 Nov 2016

Yamamoto Mika, Wakata Akihiro

Abstract excerpt

The Pig-a assay detects the expression of the endogenous phosphatidylinositol glycan anchor biosynthesis, class A gene (Pig-a) as a reporter of mutations and shows promise for detecting mutations in vivo. This assay requires two to four weeks to detect mutations in erythrocytes after animals are administered a single dose of test compound. In contrast, the more recently developed PIGRET assay using reticulocytes...

Topics

Animals
Erythrocytes
Etoposide
Membrane Proteins
Mutagenicity Tests
Mutagens
Mutation
Rats
Reticulocytes

Source

Open in PubMed

Identifiers

PMID: 27931810
DOI: 10.1016/j.mrgentox.2016.06.006

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