Article
Molecular analysis of GPI-anchor biosynthesis pathway genes in rat strains used for the Pig-a gene mutation assay.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jan 2000
Dad Azra, Dobrovolsky Vasily N, Heflich Robert H, Revollo Javier R
Abstract excerpt
Recent studies support the assumption that mutation of the X-linked Pig-a gene is most likely responsible for the mutant phenotype of the cells deficient in glycosylphosphatidylinositol (GPI)-anchored proteins quantified in the rodent Pig-a gene mutation assay. In humans, however, mutations in both alleles of one of the 30 other genes involved in GPI-anchor synthesis, e.g., PIG-L and PIG-O, cause reduced...
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