Article
Monitoring humans for somatic mutation in the endogenous PIG-a gene using red blood cells.
Environmental and molecular mutagenesis - 1 Dec 2011
Dobrovolsky Vasily N, Elespuru Rosalie K, Bigger C Anita H, Robison Timothy W, Heflich Robert H
Abstract excerpt
The endogenous X-linked PIG-A gene is involved in the synthesis of glycosyl phosphatidyl inositol (GPI) anchors that tether specific protein markers to the exterior of mammalian cell cytoplasmic membranes. Earlier studies in rodent models indicate that Pig-a mutant red blood cells (RBCs) can be induced in animals treated with genotoxic agents, and that flow cytometry can be used to identify rare RBCs deficient in...
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