Erythrocyte-Based Pig-a Gene Mutation Assay.

doi:10.1007/978-1-0716-4976-3_4

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Article

Erythrocyte-Based Pig-a Gene Mutation Assay.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2026

Bemis Jeffrey C, Hall Nikki E, Dertinger Stephen D

Abstract excerpt

In addition to chromosomal damage, assessment of gene mutation is an important part of genotoxicity testing employed during preclinical safety testing. The Pig-a gene mutation assay is based on the loss of function of the Pig-a gene, which results in a lack of cell surface expression of specific proteins that are targeted to the surface by glycosylphosphatidylinositol (GPI) anchors. This cell surface phenotype is...

Topics

Erythrocytes
Flow Cytometry
Membrane Proteins
Mutation
Mutagenicity Tests
Humans
Glycosylphosphatidylinositols
Animals

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PMID: 41273679
DOI: 10.1007/978-1-0716-4976-3_4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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