Article
Measuring reproducibility of dose response data for the Pig-a assay using covariate benchmark dose analysis.
Mutation research. Genetic toxicology and environmental mutagenesis - 15 Nov 2016
Johnson George E, Yamamoto Mika, Suzuki Yuta, Adachi Hideki, Kyoya Takahiro, Takasawa Hironao, Horibata Katsuyoshi, Tsutsumi Eri, Wada Kunio, Kikuzuki Ryuta, Yoshida Ikuma, Kimoto Takafumi, Maeda Akihisa, Narumi Kazunori
Abstract excerpt
The reproducibility of the in vivo Pig-a gene mutation test system was assessed across 13 different Japanese laboratories. In each laboratory rats were exposed to the same dosing regimen of N-nitroso-N-ethylurea (ENU), and red blood cells (RBCs) and reticulocytes (RETs) were collected for mutant phenotypic analysis using flow cytometry. Mutant frequency dose response data were analysed using the PROAST benchmark...
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