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Article

A statistical approach for analyzing data from the in vivo Pig-a gene mutation assay.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jul 2018

Igl Bernd-Wolfgang, Dertinger Stephen D, Dobrovolsky Vasily N, Raschke Marian, Sutter Andreas, Vonk Richardus

Abstract excerpt

The in vivo Pig-a gene mutation assay serves to evaluate the genotoxic potential of chemicals. In the rat blood-based assay, the lack of CD59 on the surface of erythrocytes is quantified via fluorophore-labeled antibodies in conjunction with flow cytometric analysis to determine the frequency of Pig-a mutant phenotype cells. The assay has achieved regulatory relevance as it is suggested as an in vivo follow-up...

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Identifiers

PMID: 29875075
DOI: 10.1016/j.mrgentox.2018.05.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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