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Recommendations for conducting the rodent erythrocyte Pig-a assay: A report from the HESI GTTC Pig-a Workgroup.

Environmental and molecular mutagenesis - 1 Mar 2021

Dertinger Stephen D, Bhalli Javed A, Roberts Daniel J, Stankowski Leon F, Gollapudi B Bhaskar, Lovell David P, Recio Leslie, Kimoto Takafumi, Miura Daishiro, Heflich Robert H

Abstract excerpt

The rodent Pig-a assay is a flow cytometric, phenotype-based method used to measure in vivo somatic cell mutation. An Organization for Economic Co-operation and Development (OECD) test guideline is currently being developed to support routine use of the assay for regulatory purposes (OECD project number 4.93). This article provides advice on best practices for designing and conducting rodent Pig-a studies in...

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PMID: 33608913
DOI: 10.1002/em.22427
PMCID: PMC7986863

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