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Intra- and inter-laboratory reproducibility of the rat blood Pig-a gene mutation assay.

Environmental and molecular mutagenesis - 1 Jun 2020

Dertinger Stephen D, Avlasevich Svetlana L, Torous Dorothea K, Bemis Jeffrey C, Hove Tamsanqa Tafara, O'Connell Oliver, Martus Hansjoerg, Elhajouji Azeddine

Abstract excerpt

The in vivo Pig-a assay is being used in safety studies to evaluate the potential of chemicals to induce somatic cell gene mutations. Ongoing work is aimed at developing an Organization for Economic Cooperation and Development (OECD) test guideline to support routine use for regulatory purposes (OECD project number 4.93). Among the requirements for OECD approval are demonstrations of assay reliability, including...

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PMID: 32187725
DOI: 10.1002/em.22367

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