Dual Effects of a RETN Single Nucleotide Polymorphism (SNP) at -420 on Plasma Resistin: Genotype and DNA Methylation.

doi:10.1210/jc.2016-2417

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Article

Dual Effects of a RETN Single Nucleotide Polymorphism (SNP) at -420 on Plasma Resistin: Genotype and DNA Methylation.

The Journal of clinical endocrinology and metabolism - 1 Mar 2017

Onuma Hiroshi, Tabara Yasuharu, Kawamura Ryoichi, Ohashi Jun, Nishida Wataru, Takata Yasunori, Ochi Masaaki, Nishimiya Tatsuya, Ohyagi Yasumasa, Kawamoto Ryuichi, Kohara Katsuhiko, Miki Tetsuro, Osawa Haruhiko

Abstract excerpt

CONTEXT: We previously reported that single nucleotide polymorphism (SNP)-420 C>G (rs1862513) in the promoter region of RETN was associated with type 2 diabetes. Plasma resistin was tightly correlated with SNP-420 genotypes. SNP-420 is a CpG-SNP affecting the sequence of cytosine-phosphate-guanine dinucleotides. OBJECTIVE: To examine whether methylation at SNP-420 affects plasma resistin, we analyzed plasma...

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PMID: 27929711
DOI: 10.1210/jc.2016-2417

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RETN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Dual Effects of a RETN Single Nucleotide Polymorphism (SNP) at -420 on Plasma Resistin: Genotype and DNA Methylation.PMID 27929711Read ↗

Epigenome-wide association study suggests that SNPs in the promoter region of RETN influence plasma resistin level via effects on DNA methylation at neighbouring sites.Semantic proximity Read ↗

Positive association between serum resistin and smoking was strongest in homozygotes of the G-A haplotype at c.-420 C>G and c.-358 G>A in RETN promoter: the Toon Genome Study.Semantic proximity Read ↗

A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population.Semantic proximity Read ↗

Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population.Semantic proximity Read ↗

Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese--the J-MICC Study.Semantic proximity Read ↗

Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes.Semantic proximity Read ↗

Association between the RETN -420C/G polymorphism and type 2 diabetes mellitus susceptibility: A meta-analysis of 23 studies.Semantic proximity Read ↗

Association between resistin gene -420 C/G polymorphism and the risk of type 2 diabetes mellitus: a meta-analysis.Semantic proximity Read ↗

The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3.Semantic proximity Read ↗

Genome-wide association study of plasma resistin levels identified rs1423096 and rs10401670 as possible functional variants in the Japanese population.Semantic proximity Read ↗

Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study.Semantic proximity Read ↗

Resistin expression in human monocytes is controlled by two linked promoter SNPs mediating NFKB p50/p50 binding and C-methylation.Semantic proximity Read ↗

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