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Genome-wide association study of plasma resistin levels identified rs1423096 and rs10401670 as possible functional variants in the Japanese population.

Physiological genomics - 1 Nov 2016

Kawamura Ryoichi, Tabara Yasuharu, Tsukada Akiko, Igase Michiya, Ohashi Jun, Yamada Ryo, Takata Yasunori, Kawamoto Ryuichi, Saito Isao, Onuma Hiroshi, Tanigawa Takeshi, Yamada Kazuya, Kato Norihiro, Ohyagi Yasumasa, Miki Tetsuro, Kohara Katsuhiko, Osawa Haruhiko

Abstract excerpt

Resistin is a cytokine inducing insulin resistance in mice. We previously identified single nucleotide polymorphisms (SNPs) at -420 (rs1862513) and -358 (rs3219175) located in the human resistin gene (RETN) promoter as strong determinants for circulating resistin in the Japanese population. The objective was to identify additional functional variants for circulating resistin. We conducted a genome-wide...

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Identifiers

PMID: 27664181
DOI: 10.1152/physiolgenomics.00040.2016

Genes

RETN

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Genome-wide association study of plasma resistin levels identified rs1423096 and rs10401670 as possible functional variants in the Japanese population.PMID 27664181Read ↗

Positive association between serum resistin and smoking was strongest in homozygotes of the G-A haplotype at c.-420 C>G and c.-358 G>A in RETN promoter: the Toon Genome Study.Semantic proximity Read ↗

Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population.Semantic proximity Read ↗

Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population.Semantic proximity Read ↗

A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population.Semantic proximity Read ↗

Circulating resistin levels and mutation burden of the RETN gene variants predict long-term mortality in a Taiwanese population.Semantic proximity Read ↗

Plasma resistin is associated with single nucleotide polymorphisms of a possible resistin receptor, the decorin gene, in the general Japanese population.Semantic proximity Read ↗

Epigenome-wide association study suggests that SNPs in the promoter region of RETN influence plasma resistin level via effects on DNA methylation at neighbouring sites.Semantic proximity Read ↗

Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study.Semantic proximity Read ↗

Novel resistin promoter polymorphisms: association with serum resistin level in Japanese obese individuals.Semantic proximity Read ↗

Common quantitative trait locus downstream of RETN gene identified by genome-wide association study is associated with risk of type 2 diabetes mellitus in Han Chinese: a Mendelian randomization effect.Semantic proximity Read ↗

The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3.Semantic proximity Read ↗

Resistin G-A haplotype at SNP-420/-358 is associated with the latent sarcopenic obesity index in the toon genome study.Semantic proximity Read ↗

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