Article
The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3.
American journal of human genetics - 1 Oct 2004
Osawa Haruhiko, Yamada Kazuya, Onuma Hiroshi, Murakami Akiko, Ochi Masaaki, Kawata Hiroko, Nishimiya Tatsuya, Niiya Toshiyuki, Shimizu Ikki, Nishida Wataru, Hashiramoto Mitsuru, Kanatsuka Azuma, Fujii Yasuhisa, Ohashi Jun, Makino Hideichi
Abstract excerpt
Insulin resistance is a major cause of type 2 diabetes mellitus (T2DM). Resistin, an adipocyte-secreted hormone, antagonizes insulin. Transgenic mice that overexpress the resistin gene (Retn) in adipose tissue are insulin-resistant, whereas Retn (-/-) mice show lower fasting blood glucose, suggesting that the altered Retn promoter function could cause diabetes. To determine the role of RETN in human T2DM, we...
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