Article
Resistin expression in human monocytes is controlled by two linked promoter SNPs mediating NFKB p50/p50 binding and C-methylation.
Scientific reports - 23 Oct 2019
Kumar Dilip, Lee Bernett, Puan Kia Joo, Lee Wendy, Luis Boris San, Yusof Nurhashikin, Andiappan Anand Kumar, Del Rosario Ricardo, Poschmann Jeremie, Kumar Pavanish, DeLibero Gennaro, Singhal Amit, Prabhakar Shyam, De Yun Wang, Poidinger Michael, Rötzschke Olaf
Abstract excerpt
Resistin is a key cytokine associated with metabolic and inflammatory diseases. Especially in East Asian populations, the expression levels are strongly influenced by genetic polymorphisms. Mechanisms and functional implications of this genetic control are still unknown. By employing reporter assays, EMSA, inhibition studies, bisulphite sequencing, ChIP-Seq and gene-editing we show that the p50/p50 homodimer...
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