Positive association between serum resistin and smoking was strongest in homozygotes of the G-A haplotype at c.-420 C>G and c.-358 G>A in RETN promoter: the Toon Genome Study.

doi:10.1038/s10038-023-01176-8

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Positive association between serum resistin and smoking was strongest in homozygotes of the G-A haplotype at c.-420 C>G and c.-358 G>A in RETN promoter: the Toon Genome Study.

Journal of human genetics - 1 Nov 2023

Hadate Toshimi, Kawamura Ryoichi, Tabara Yasuharu, Maruyama Koutatsu, Takakado Misaki, Ikeda Yosuke, Ohashi Jun, Takata Yasunori, Saito Isao, Osawa Haruhiko

Abstract excerpt

Resistin is mainly expressed in human monocytes/macrophages and is associated with insulin resistance, inflammation, and atherosclerosis. Serum resistin is strongly correlated with the G-A haplotype defined by single nucleotide polymorphisms (SNPs) c.-420 C>G (SNP-420) (rs1862513) and c.-358 G>A (SNP-358) (rs3219175) in the promoter region of the human resistin gene (RETN). Smoking is also associated with insulin...

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Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homozygote

Japan

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Resistin

Smoking

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PMID: 37423942
DOI: 10.1038/s10038-023-01176-8

Genes

RETN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Positive association between serum resistin and smoking was strongest in homozygotes of the G-A haplotype at c.-420 C>G and c.-358 G>A in RETN promoter: the Toon Genome Study.PMID 37423942Read ↗

Genome-wide association study of plasma resistin levels identified rs1423096 and rs10401670 as possible functional variants in the Japanese population.Semantic proximity Read ↗

A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population.Semantic proximity Read ↗

Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population.Semantic proximity Read ↗

Resistin G-A haplotype at SNP-420/-358 is associated with the latent sarcopenic obesity index in the toon genome study.Semantic proximity Read ↗

Epigenome-wide association study suggests that SNPs in the promoter region of RETN influence plasma resistin level via effects on DNA methylation at neighbouring sites.Semantic proximity Read ↗

Circulating resistin levels and mutation burden of the RETN gene variants predict long-term mortality in a Taiwanese population.Semantic proximity Read ↗

Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population.Semantic proximity Read ↗

Polymorphisms of the resistin gene and their association with obesity and resistin levels in Malaysian Malays.Semantic proximity Read ↗

Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese--the J-MICC Study.Semantic proximity Read ↗

An inverse association between serum resistin levels and n-3 polyunsaturated fatty acids intake was strongest in the SNP-420 G/G genotype in the Japanese cohort: The Toon Genome Study.Semantic proximity Read ↗

Common quantitative trait locus downstream of RETN gene identified by genome-wide association study is associated with risk of type 2 diabetes mellitus in Han Chinese: a Mendelian randomization effect.Semantic proximity Read ↗

Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study.Semantic proximity Read ↗

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