A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population.

doi:10.1371/journal.pone.0009718

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Article

A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population.

PloS one - 16 Mar 2010

Onuma Hiroshi, Tabara Yasuharu, Kawamura Ryoichi, Tanaka Takashi, Ohashi Jun, Nishida Wataru, Takata Yasunori, Ochi Masaaki, Yamada Kazuya, Kawamoto Ryuichi, Kohara Katsuhiko, Miki Tetsuro, Makino Hideichi, Osawa Haruhiko

Abstract excerpt

Insulin resistance is a feature of type 2 diabetes. Resistin, secreted from adipocytes, causes insulin resistance in mice. We previously reported that the G/G genotype of single nucleotide polymorphism (SNP) at -420 (rs1862513) in the human resistin gene (RETN) increased susceptibility to type 2...

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PMID: 20300528
DOI: 10.1371/journal.pone.0009718
PMCID: PMC2838794

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RETN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20300528-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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A at single nucleotide polymorphism-358 is required for G at -420 to confer the highest plasma resistin in the general Japanese population.PMID 20300528Read ↗

Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population.Semantic proximity Read ↗

Positive association between serum resistin and smoking was strongest in homozygotes of the G-A haplotype at c.-420 C>G and c.-358 G>A in RETN promoter: the Toon Genome Study.Semantic proximity Read ↗

Genome-wide association study of plasma resistin levels identified rs1423096 and rs10401670 as possible functional variants in the Japanese population.Semantic proximity Read ↗

The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3.Semantic proximity Read ↗

[Role of resistin in insulin resistance].Semantic proximity Read ↗

Association between resistin gene -420 C/G polymorphism and the risk of type 2 diabetes mellitus: a meta-analysis.Semantic proximity Read ↗

Resistin G-A haplotype at SNP-420/-358 is associated with the latent sarcopenic obesity index in the toon genome study.Semantic proximity Read ↗

Genetic variants of resistin and its plasma levels: Association with obesity and dyslipidemia related to type 2 diabetes susceptibility.Semantic proximity Read ↗

Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese--the J-MICC Study.Semantic proximity Read ↗

Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population.Semantic proximity Read ↗

Resistin SNP-420 determines its monocyte mRNA and serum levels inducing type 2 diabetes.Semantic proximity Read ↗

Association between the RETN -420C/G polymorphism and type 2 diabetes mellitus susceptibility: A meta-analysis of 23 studies.Semantic proximity Read ↗

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