Article
Association of the Cholinergic Muscarinic M2 Receptor with Autonomic Nervous System Activity in Patients with Schizophrenia on High-Dose Antipsychotics.
Neuropsychobiology - 1 Jan 2016
Miyauchi Masatoshi, Kishida Ikuko, Suda Akira, Shiraishi Yohko, Hattori Saki, Fujibayashi Mami, Taguri Masataka, Ishii Chie, Ishii Norio, Moritani Toshio, Hirayasu Yoshio
Abstract excerpt
BACKGROUND: Patients with schizophrenia have abnormal autonomic nervous system (ANS) activity compared with the general population. One reason for this difference is the muscarinic affinity for antipsychotic drugs; therefore, single nucleotide polymorphisms (SNPs) of the muscarinic receptor gene influence this ANS dysfunction. This study sought to determine the effect of SNPs of the cholinergic muscarinic...
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