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Article

Genetic Polymorphisms Associated With Constipation and Anticholinergic Symptoms in Patients Receiving Clozapine.

Journal of clinical psychopharmacology - 1 Jun 2018

Solismaa Anssi, Kampman Olli, Lyytikäinen Leo-Pekka, Seppälä Niko, Viikki Merja, Mononen Nina, Lehtimäki Terho, Leinonen Esa

Abstract excerpt

BACKGROUND: Clozapine impairs gastrointestinal motility owing to its anticholinergic and antiserotonergic properties. This commonly leads to constipation and potentially to more severe complications such as bowel obstruction and ischemia. The aim of this study was to determine whether genetic variations in the genes encoding muscarinic and serotonergic receptors (CHRM2, CHRM3, HTR2, HTR3, HTR4, and HTR7) explain...

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Source

Identifiers

PMID: 29620694
DOI: 10.1097/JCP.0000000000000885

Genes

CHRM3
ABCB1
CHRM2
HTR7
OPRM1
TPH1
COMT
HTR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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