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Article

The association of genetic polymorphisms in CYP1A2, UGT1A4, and ABCB1 with autonomic nervous system dysfunction in schizophrenia patients treated with olanzapine.

BMC psychiatry - 18 Feb 2020

Hattori Saki, Suda Akira, Miyauchi Masatoshi, Shiraishi Yohko, Saeki Takashi, Fukushima Tadashi, Fujibayashi Mami, Tsujita Natsuki, Ishii Chie, Ishii Norio, Moritani Tosiho, Saigusa Yusuke, Kishida Ikuko

Abstract excerpt

BACKGROUND: Use of the antipsychotic drug olanzapine by patients with schizophrenia is associated with autonomic nervous system (ANS) dysfunction. It is presumed that there are interindividual differences in ANS dysfunction that correspond to pharmacogenetics. In this study, we investigated whether genetic polymorphisms in ABCB1, CYP1A2, and UGT1A4 are associated with this observed ANS dysfunction. METHODS: A...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP1A2

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Identifiers

PMID: 32070304
DOI: 10.1186/s12888-020-02492-5
PMCID: PMC7027321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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