Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1 expression in the postmortem brain and responsiveness to antipsychotics.

doi:10.1016/j.jpsychires.2023.08.007

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Article

Ethnicity-dependent effect of rs1799971 polymorphism on OPRM1 expression in the postmortem brain and responsiveness to antipsychotics.

Journal of psychiatric research - 1 Oct 2023

Miyahara Kazusa, Hino Mizuki, Shishido Risa, Izumi Ryuta, Nagaoka Atsuko, Hayashi Hideki, Kakita Akiyoshi, Yabe Hirooki, Tomita Hiroaki, Kunii Yasuto

Abstract excerpt

Schizophrenia is associated with aberration of inhibitory neurons. Although the mu-opioid receptor (MOR) is an essential modulator of inhibitory neurons, the effect of rs1799971 polymorphism in the MOR gene on risk of schizophrenia is controversial. Moreover, the disturbance of opioids systems in patients with schizophrenia has not been fully examined. We firstly conducted preliminary meta-analyses integrating...

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PMID: 37659266
DOI: 10.1016/j.jpsychires.2023.08.007

Genes

OPRM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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