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Article

Cholinergic muscarinic M4 receptor gene polymorphisms: a potential risk factor and pharmacogenomic marker for schizophrenia.

Schizophrenia research - 1 May 2013

Scarr Elizabeth, Um Jung Yoon, Cowie Tiffany Frances, Dean Brian

Abstract excerpt

Although schizophrenia is a widespread disorder of unknown aetiology, we have previously shown that muscarinic M4 receptor (CHRM4) expression is decreased in the hippocampus and caudate-putamen from subjects with the disorder, implicating the receptor in its pathophysiology. These findings led us to determine whether variation in the CHRM4 gene sequence was associated with an altered risk of schizophrenia by...

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Source

Identifiers

PMID: 23490763
DOI: 10.1016/j.schres.2013.01.023

Genes

CHRM4

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