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Article

Histaminergic gene polymorphisms associated with sedation in clozapine-treated patients.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 May 2017

Solismaa Anssi, Kampman Olli, Lyytikäinen Leo-Pekka, Seppälä Niko, Viikki Merja, Mononen Nina, Lehtimäki Terho, Leinonen Esa

Abstract excerpt

Sedation is a common adverse effect of clozapine treatment, which may be partly related to clozapine binding to histamine receptors in the central nervous system. The objective of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the histaminergic system are associated with sedation in clozapine-treated patients. The study population comprised 237 clozapine-treated, Finnish,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28400155
DOI: 10.1016/j.euroneuro.2017.03.009

Genes

HNMT
AOC1
HRH1

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