Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphism in alpha 2A adrenergic receptor gene is associated with sialorrhea in schizophrenia patients on clozapine treatment.

Human psychopharmacology - 1 Jul 2014

Solismaa Anssi, Kampman Olli, Seppälä Niko, Viikki Merja, Mäkelä Kari-Matti, Mononen Nina, Lehtimäki Terho, Leinonen Esa

Abstract excerpt

OBJECTIVE: Clozapine-induced sialorrhea (CIS) is a common, inconvenient and socially stigmatizing adverse effect. The pathophysiology of CIS may be related to the effect of clozapine on the muscarinic and adrenergic receptors as well as the disruption of the circadian rhythms. The aim of this study was to find out if polymorphisms in muscarinic M1 and M3 receptor genes (CHRM1 and CHRM3), adrenoceptor alpha 2A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antipsychotic Agents
Share to CLOCK Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clozapine

Share to Finland

Share to Genotyping Techniques

Share to Receptor, Muscarinic M3

Share to Receptors, Adrenergic, alpha-2

Share to Receptors, Muscarinic

Source

Identifiers

PMID: 25163438
DOI: 10.1002/hup.2408

Genes

CHRM1
CHRM3
CLOCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphism in alpha 2A adrenergic receptor gene is associated with sialorrhea in schizophrenia patients on clozapine treatment.PMID 25163438Read ↗

Polymorphisms in ERBB4 and TACR1 associated with dry mouth in clozapine-treated patients.Semantic proximity Read ↗

Clozapine efficacy and adverse drug reactions among a nationwide study of 1021 Australians prescribed clozapine: The ClozaGene StudySemantic proximity Read ↗

No evidence for association of alpha 1a adrenoceptor gene polymorphism and clozapine-induced urinary incontinence.Semantic proximity Read ↗

Histaminergic gene polymorphisms associated with sedation in clozapine-treated patients.Semantic proximity Read ↗

Association of the Cholinergic Muscarinic M2 Receptor with Autonomic Nervous System Activity in Patients with Schizophrenia on High-Dose Antipsychotics.Semantic proximity Read ↗

Predictors of Extrapyramidal Side Effects among Patients Taking Antipsychotic Medication at Mekelle Psychiatry Units, Northern Ethiopia, 2023: Unmatched Case-Control StudySemantic proximity Read ↗

Genetic dissection of drug effects in clinical practice: CLOCK gene and clozapine-induced diurnal sleepiness.Semantic proximity Read ↗

[Association of single-nucleotide variants of ABCG2 and ABCB1 genes with clinical and laboratory parameters during clozapine therapy].Semantic proximity Read ↗

Aripiprazole once-monthly as treatment for psychosis in Turner syndrome: literature review and case report.Semantic proximity Read ↗

Clozapine-induced agranulocytosis and its genetic determinants.Semantic proximity Read ↗

Development of asymptomatic pancreatitis with paradoxically high serum clozapine levels in a patient with schizophrenia and the CYP1A2*1F/1F genotype.Semantic proximity Read ↗

Association analysis of polymorphism in the promoter region of the alpha2a-adrenoceptor gene with schizophrenia and clozapine response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.